Endocrine Abstracts

A new genetic disorder has recently been identified that results from mutation of THRA, encoding thyroid hormone receptor α1 (TRα1). Affected children have a high serum T3:T4 ratio, constipation and a variable intellectual deficit, but exhibit a consistently severe skeletal dysplasia. Similar to these patients, Thra1PV/+ mice harbour a mutation that disrupts the C-terminal α-helix of TRα1 and express a domi...

Aim: Suicide and depression are one of the highest public health problems worldwide. Suicidal ideation represents an important phase in the suicidal process and often precedes suicidal attempts or completed suicide. Patients with chronic medical disease are more likely to report suicidal thoughts and depression. However the studies on relationship between these conditions and metabolic syndrome are rare. We aimed at investigating the prevalence of depression and suicidal ideat...

Introduction: Rutin (C27H30O16) is the major representative of the flavonol subclass of flavonoids. Rutin has wide variety of pharmacological activity, however there are not sufficient data in 3T3-L1 preadipocyte. In this study, we demonstrated that the effect of rutin on the proliferation of 3T3-L1 preadipocyte.Methods: The 3T3-L1 preadipocyte were treated with homocysteine (1 mM), rutin (30 μM) and rutin after homo...

Background: The body mass index (BMI) is the most widely used method of assessing fat accumulation, and is recognized as an independent risk factor for cardiometabolic diseases. However, there might be substantial variations in the fat or muscle amount among persons with a similar BMI. The aim of the present study was to investigate whether BMI and skeletal muscle mass (SMM) estimated from by bioelectrical impedance analysis (BIA) are associated with carotid atherosclerosis in...

Introduction: Calbindin-D9k is a 9 kDa polypeptide expressed in the mammalian intestine, uterus, and pituitary gland. Calbindin-D9k increase Ca2+ absorption by buffering intracellular Ca2+. The intracellular concentration of calcium is regulated by calcium related proteins such as calbindin-D9k, TRPV1 and PMCA1. The regulatory effect of steroid hormones and glucocorticoids on calbindin-D9k, TRPV1 and PMCA1 expre...

Background: BoneXpert software calculates bone health index (BHI) from 100 measurements of cortical thickness and mineralisation of three metacarpals. BHI-SDS is derived from 3,121 X-rays from 231 healthy Caucasian children, corrected for bone age (BA), estimated from the same x-ray.BHI-SDS is new with relatively unknown clinical utility. Strong correlations between BHI and dual-energy x-ray (DXA) absorptiometry and peripheral quantitative computed CT me...

Background: The association between thyroid cancer and skeletal outcomes has not been thoroughly investigated. We aimed to investigate the risk of osteoporotic fractures in patients with thyroid cancer compared with a matched control group.Methods: This retrospective cohort study included 2,514 patients with thyroid cancer and 75,420 matched controls from the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC, 2006-2019). Rates of ...

Background: We aimed to explore the relationship between continuous glucose monitoring (CGM)-derived indicators and the presence of albuminuria taking circadian features into consideration concurrently in Insulin-using patients with type 2 diabetes.Methods: We analyzed data from 129 insulin-treated type 2 diabetes patients in Korea University Ansan Hospital. Over 10 days, we collected time-series data using Dexcom G6, Fitbit, and food diaries, along with...

The defining feature of endometriosis is that endometrial tissues are deposited and grown onto sites outside of the uterine cavity. The pathogenesis of endometriosis, however, remains controversial despite extensive research. Since the endometriosis has been known as an estrogen-dependent inflammatory disease, the alterations in estrogen-mediated cellular signaling play an essential role in the pathogenesis of endometriosis. In addition to higher estrogen receptor (ER)β l...

Aim/hypotheses: Ectopic lipid accumulation in the heart contributes to the abnormal function of the heart and to the death of cardiomyocytes. Saturated FFA is one of the most important causes of death in cardiomyocytes. Although empagliflozin has been reported to be beneficial for people with diabetic complications and/or CVD, it has not been confirmed as to how it affects cardiomyocytes death by FFA. This study was designed to evaluate the protective effects of SGLT2 inhibito...